How does Diabetes Affect Your Body?
High blood sugar levels can affect your entire body. Many people with high blood glucose levels may initially feel normal and not realise that the high blood glucose level is silently doing damage.
Diabetes is a chronic condition that can impact other functions of the body including the: Feet, Toes and Skin
What is Diabetes?
Diabetes is a condition characterised by high levels of glucose (or sugar) in the blood. When a person has a high blood sugar level they are said to be hyperglycaemic.
Glucose is essential for providing the body with energy. The body converts many of the foods that we eat into glucose. A hormone called insulin is required to transfer glucose from the bloodstream to the body’s cells.
If you suspect or know you have diabetes it is important to speak with your doctor to seek testing and advice on how to best manage your diabetes.
What is the Cause of Diabetes?
Diabetes occurs when there is not enough insulin to help get the glucose out of the bloodstream and into the body’s cells.
All types of diabetes lead to high blood glucose levels. The most common are Type 2 Diabetes Mellitus, Type 1 Diabetes Mellitus and Gestational Diabetes Mellitus. Each diabetes type has a different cause. (please see “What are the types of diabetes”).
High blood glucose levels usually occur because:
- The pancreas is unable to produce any or enough insulin. This happens in Type 1 Diabetes Mellitus
OR
- The body’s cells are resistant to the action of insulin (insulin resistance). This occurs in Type 2 Diabetes Mellitus
What Part does the Pancreas Play in Diabetes?
The pancreas is a leaf-shaped gland located behind the stomach. It is responsible for the production of insulin, which is the hormone that helps regulate blood glucose levels.
After a meal, the blood glucose level rises, causing the pancreas to normally release insulin into the blood. In a healthy person, the insulin allows the body’s cells to absorb glucose so it can be used as energy. When there is enough insulin, the blood sugar levels stay in the normal range.
For people living with diabetes, there are two main reasons why the blood sugar levels are high. This is because either:
- Little or no insulin is produced by the pancreas, or
- The body’s cells are resistant to the action of insulin.
This results in glucose being unable to enter the cells and therefore we see increased blood glucose levels (sometimes known as hyperglycaemia).
What are the Types of Diabetes?
Type 1 Diabetes Mellitus:
Type 1 Diabetes Mellitus is caused by an autoimmune condition, where a person’s own immune system attacks the cells of the pancreas which produce insulin. This leads to very low levels of insulin. Its onset is often sudden and without warning. There is currently no way of preventing it and no cure. People living with Type 1 Diabetes Mellitus do not produce any insulin and need insulin treatment to survive. This insulin can be given either by multiple injections per day or via an insulin pump.
Type 1 Diabetes accounts for around 10% of all diagnosed cases of diabetes.
People living with Type 1 Diabetes Mellitus can lead a normal, long and healthy life with the right support of family, friends, medical team along with medications, insulin and new technology.
Another term for Type 1 Diabetes Mellitus is Juvenile Diabetes – however adults can also develop Type 1 Diabetes Mellitus.
Type 2 Diabetes Mellitus:
Type 2 Diabetes Mellitus is caused by the inability of the pancreas to produce enough insulin and/or the body’s cells being resistant to the action of insulin. It is the most common type and accounts for around 85-90% of all diagnoses of diabetes.
Type 2 diabetes is a condition that gradually progresses over time.
While there is no cure for the condition, it can be managed. People with Type 2 diabetes can lead normal, healthy and happy lives.
Lifestyle changes, such as exercising and improving your diet, are effective ways to treat Type 2 Diabetes Mellitus. People with Type 2 Diabetes Mellitus may also need medications to treat their condition depending on the severity of the condition. Along with lifestyle changes the medications may be a combination of tablets and/or injections.
MODY (Maturity Onset Diabetes of the Young):
MODY is caused by a single abnormal gene. It accounts for approximately 1-2% of all diabetes diagnoses and is caused by a genetic mutation that is often passed down in families.It is a rare form of diabetes that is different to Type 1 and Type 2 Diabetes Mellitus.
People with MODY are often diagnosed before the age of 25.
The treatment is often tablets or sometimes a combination of tablets and insulin injections.
Secondary Diabetes Mellitus:
Secondary diabetes occurs when the pancreas is damaged and unable to make insulin. Sometimes it is referred to as Type 3 Diabetes Mellitus.
Secondary diabetes is most commonly caused by pancreatitis or inflammation of the pancreas. Examples of common causes of secondary diabetes mellitus include:
- Pancreatitis
- Haemochromatosis
- Cystic fibrosis
- Trauma to the pancreas
- Pancreas surgery such as pancreatectomy
- Pancreatic agenesis
- Pancreatic cancer
Gestational Diabetes Mellitus:
Gestational diabetes is diabetes that first appears during pregnancy.
Approximately 12-14% of pregnant women will develop the condition around the 24th to 28th week of pregnancy.
It is important to remember that sometimes women who have no risk factors may develop Gestational diabetes. Therefore, all women should be tested for the condition between the 26th to 28th week of pregnancy or earlier if you have multiple risk factors for the condition.
Gestational diabetes needs to be monitored closely by the health care team as poorly controlled blood glucose levels can have severe impacts on both the health of the mother and baby.
Gestational diabetes is often managed simply with changes to diet and exercise, however some women may require tablets, insulin injections or both.
Once women with gestational diabetes give birth, the diabetes should go away. However, women who have had gestational diabetes are at greater risk for developing Type 2 Diabetes Mellitus in the future and require lifelong screening.
Risk Factors for Developing Type 1 Diabetes
- Anyone can get Type 1 diabetes - it does not discriminate. People who have a family history of diabetes eg. a parent or sibling with type 1 diabetes or genetic predisposition are at increased risk of type 1 diabetes.
- Sometime triggers like infections can make people more at risk to autoimmune conditions like Type 1 Diabetes Mellitus
Risk Factors for Developing Type 2 Diabetes
There are many factors which may put a person at increased risk of developing this condition. Some of these include:
- Family history of diabetes
- Being overweight or obese
- Being over 45 years old
- Genetics, especially people from some cultural backgrounds (Aboriginal and Torres Strait Islander, Pacific Islander, Indian and Chinese)
- Women who have previously had Gestational diabetes while pregnant.
- Unhealthy diet
- Sedentary lifestyle
- Having high blood pressure
- Having abnormal cholesterol levels in blood
Risk Factors for Developing Secondary Diabetes
- Pancreatitis
- Pancreas surgery or removal of the pancreas
- Medical conditions that can be associated with damage to the pancreas such as cystic fibrosis
Risk Factors for Developing Gestational Diabetes
Only pregnant women can develop gestational diabetes. The risk factors include:
- Being over the age of 40
- Having a mother or sister with a history of Type 2 or Gestational diabetes
- Being overweight or rapidly gaining excessive weight in the first trimester of pregnancy
- Cultural background (Aboriginal or Torres Strait Islander, Melanesian, Polynesian, Chinese, Southeast Asian, Middle Eastern or Indian)
- History of Polycystic Ovarian Syndrome
- Gestational diabetes in previous pregnancies
- History of large birth weight (greater than 4.5kg) in previous pregnancies.
How Often should I See My Doctor to Assess My Risk of Diabetes?
Everyone over the age of 40 should be screened for diabetes every three years using a risk calculator like AUSDRISK.
Aboriginal and Torres Strait Islander people should begin having AUSDRISK assessments from the age of 18.
Did you know?
Half a million Australians could have Type 2 Diabetes Mellitus but don’t know it!
What are the Symptoms of Diabetes?
The main symptoms of
Type 2 Diabetes Mellitus
are:
- Increased thirst and drinking
- Hunger
- Frequent urination
- Tiredness
- Increased infections
- Blurry vision
- Dark pigmentation in certain parts of the body
- Some people may have no symptoms at all and not know they have diabetes
The main symptoms of Type 1 Diabetes Mellitus
are the 4 T’s:
- Thirst (feeling thirsty and needing to drink more fluids)
- Toilet (needing to urinate more frequently)
- Thinner (weight loss)
- Tired
As insulin production declines, a patient may develop:
- Stomach pain
- Vomiting
- Become very ill
Whatever the type of diabetes if there is sustained, uncontrolled high blood sugar (hyperglycaemia) it can damage the heart, blood vessels, eyes, kidneys and nerves. If you are at risk, see your doctor early to prevent this damage from happening.
Diabetes complications start before diagnosis- If you have risk factors for diabetes do not delay seeing your doctor
- As many as half of all people diagnosed with diabetes already have developed one or more diabetes related complications
You can find more about diabetes by watching this video clip
Diagnostic Tests for Type 2 Diabetes
There are different ways for your doctor to diagnose diabetes
- Fasting (pre-meal) blood glucose level more than 7.0 mmol/L
- Random blood glucose level more than 11.1 mmol/L
- Glycated haemoglobin (HbA1c) more than 48 mmol/mol (6.5%; on two separate occasions)
Other tests used to determine a patient's type of diabetes, stage, progression, treatment pathways or effective diabetes management are:
Urine Test:
This is done to check for the presence of protein, glucose or ketones in the urine. Presence of glucose in the urine is highly suggestive of diabetes. Presence of protein in the urine can suggest the kidneys are damaged or “leaky” and may be a sign of renal failure.
HbA1c Test:
HbA1c is a measure of how much glucose is stuck to the red cells and gives an average of all your blood sugar levels over the last three months.
Target HbA1c is usually individualised for each patient:
- For most people living with diabetes the target HbA1c is ideally less than 7% (53 mmol/mol) to reduce the chance of long term diabetes complications.
- For young people or women planning pregnancy the target HbA1c may be lower at around 6.5% (48 mmol/mol) or less.
Oral Glucose Tolerance Test:
This is done to confirm Type 2 Diabetes and Gestational Diabetes Mellitus.
Following an overnight fast, your blood is tested for glucose. This is compared with periodic blood tests taken for the next two hours after drinking a special sugar drink.
It measures how quickly glucose can be cleared from the blood.
Fasting Blood Sugar Test:
- The blood sugar level is tested after an overnight fast.
- Levels of 5.5mmol/L to 6.9 mmol/L is inferred as pre-diabetes
- Levels more than 6.9mmol/L on two or more separate tests on different days indicates diabetes.
Random Blood Sugar Test:
- Blood is tested at a random time of the day for glucose levels. For example, this may be after a meal.
- Blood glucose levels of 11.1 mmol/L or higher indicates diabetes.
Watch this video find out why it is important to detect diabetes early
Treatments for Type 2 Diabetes
There is no such thing as ‘mild’ diabetes. All types of diabetes are serious and require life long follow up and management in combination with a healthy lifestyle and often medications.
Management of Type 2 Diabetes is with lifestyle changes and often medications.
Watch this video to find out more about managing type 2 diabetes
Lifestyle Changes
- Healthy eating
- Increased physical activity
- Healthy body weight
- Quitting smoking
Medication
Along with healthy eating, weight control, increased physical activity and diabetes education, medications are needed for some people. Medications can be taken either orally or as injections.
Examples of classes of medications that may be used include:
- Biguanides (Metformin)
- Sulfonylurea
- Thiazolidinedione
- DPP-4 inhibitor
- SGLT-2 inhibitor
- GLP-1 agonist
- Insulin
Each of the different class of medications has different levels of efficacy, side-effects, impact on weight loss, varying costs and risks of hypoglycaemia.In Australia most, but not all, of the medications used for treating diabetes are subsidised by the government PBS (Pharmaceutical Benefits Scheme). Visiting an endocrinologist can help to individualise the right management plan for you.
How Often do I Need to Check My Blood Sugar Level if I am on Insulin?
If you are on insulin, routine self-monitoring of your blood glucose is recommended.
The type of insulin you are on and the type of diabetes that you have will determine how often you will need to check your glucose level. It may include checking your blood glucose:
- Before food
- Before going to bed
- Before driving
- Before exercise
- If you think you have symptoms of a low blood glucose level (hypoglycaemia)
- Or a combination of these
You will need to check with your doctor to find out what is best for you and how often you need to check.
How Often do I Need to Check My Blood Sugar Level if I am on Tablets (not Insulin)?
If you are on tablets that do not cause hypoglycaemia you may not need to routinely monitor your blood sugar level. Instead your doctor may organise routine HbA1c levels to measure your 3 monthly average glucose level.
What should My Target Blood Glucose Level be?
The ideal target for everyone with diabetes will vary. Talk to your doctor about what the right targets should be for you. In general targets for blood glucose levels are:
- Fasting blood glucose level of 4-7 mmol/L
- Post meal blood glucose level of 6–10 mmol/L
Blood glucose levels should be individualised. If you are young or planning pregnancy lower blood sugar levels may be recommended. For some people, such as those with cancer or dementia, higher blood sugar levels may be ok.
With the right treatment you can prevent diabetes causing complications.
Facts and Figures:- 60% of Australians with type 2 diabetes will experience some form of diabetes related eye disease within 20 years of developing diabetes.
- Diabetes is the leading cause of end stage kidney disease.
- Around 65% of all cardiovascular disease related deaths in Australia occur in people with diabetes or prediabetes.
How can You Reduce Your Risk of Diabetes Complications?
There are three important ways to reduce your risk of developing long term, irreversible diabetes complications:
- Aiming for optimal blood glucose control
- Aiming for a blood pressure of less than 140/90 mmHg
- Regular screening tests to pick up early changes before any damage has occurred.
What Screening Tests do You Need if You Live with Type 2 Diabetes Mellitus?
Regular screening tests can reduce your risk of long term diabetes related complications.Your diabetes care plan or annual cycle of care will include regular tests and screening:
Feet & Nerves
Routine foot checks with GP or podiatrist. If there is numbness or diabetic neuropathy than you will need to take special care of your feet.- Inspect your feet regularly.
- Wash, dry and look at your feet every day, especially between your toes.
- Always wear well fitting shoes.
- See you doctor early if you develop an ulcer or signs of an infection such as redness or swelling.
- You may need to have scans to check blood flow in the feet or see a surgeon if you have wounds on your legs or feet that won’t heal.
Management of Type 1 Diabetes
The management of Type 1 Diabetes involves a combination of
- Insulin by multiple daily injections or insulin pump
- Exercise
- Healthy diet
- Regular blood sugar measurements.
People living with Type 1 Diabetes need regular specialist care as their medical needs change and to screen for potential diabetes related complications. Activities and illness also affect their treatments.
Insulin Treatment in Type 1 Diabetes
Insulin is essential for people with type 1 diabetes as the body produces little or no insulin. Without insulin, people with type 1 diabetes cannot survive. Whether you have an insulin pump or give multiple daily insulin injections, it is recommended that you:
- Monitor your blood glucose levels regularly
- Bolus for insulin if your blood glucose level is high
- Bolus for insulin if you are eating carbohydrate containing foods
- Learn to carbohydrate count so you can match the amount of insulin given with the amount of carbohydrate in the food
- Adjust your insulin doses depending on activities such as exercise or work and illness
- See your GP and endocrinologist routinely
- Have routine screening for diabetes complications
Success requires work and effort. If you are willing to work at it, you will see the rewards!
Types of Insulin Used in Type 1 Diabetes
There are two main types of insulin.
Basal insulin
Basal insulin is also known as background insulin. This mimics the body’s natural steady release of insulin. When basal insulin is given it is absorbed slowly and gives the body a steady, low level of insulin to manage blood glucose.
Examples of basal insulin include Lantus (insulin glargine) and Levemir (insulin detemir). Alternatively, giving small continuous amounts of quick acting insulin via an insulin pump acts as basal insulin.
Quick Acting Insulin
A bolus of quick acting insulin is taken to cover the rise in blood sugar with food and/or if blood sugar levels are high. This mimics the body’s large peaks in insulin that are normally released in response to food or a high blood glucose level.
Quick acting insulins can be given via:
- Pens
- Needle and syringe
- As a bolus via a insulin pump
Examples of quick acting insulin include Humalog (Lispro), Novorapid (Aspart) or Apidra (Glulisine).
Quick acting insulin is usually best taken 10-15 minutes before a meal. This is so that the insulin is “kicking in” and reaching its peak effect as you are about to digest the meal.
How Long does Insulin Last?
Depending on which type of insulin and how much insulin you take will determine how long an insulin will last.
Common insulin profiles include: